In the realm of clinical research, the accuracy of patient feedback is paramount. This is where Cognitive Debriefing comes into play, particularly in the translation of patient questionnaires. These specialized interviews are a cornerstone of linguistic validation, ensuring that Patient-Reported Outcomes (PROs) are not just linguistically accurate but also culturally relevant and understandable across diverse populations. Cognitive Debriefing is a process embedded within the translation of clinical instruments. When patients from different linguistic backgrounds are required to provide information about their health and treatment experiences, the clarity of each translated questionnaire item is crucial. Cognitive Debriefing allows researchers to evaluate not just the translation’s validity, but also its relevance and accessibility to the target demographic.